HTH RS M 733 / Statistical and Methodologic Issues in Randomized Clinical Trials

3 unit(s)

Prerequisite(s): HTH RS M 702 and HTH RS M 730

This course will consider important statistical issues relating to the design, analysis and interpretation of randomized clinical trials. Specific topics will include issues in large simple trials, factorial designs, cluster randomization, cross-over trials, missing data in RCTs, repeated measures in RCTs, meta-analysis, non-inferiority trials, subgroup analysis, composite outcomes in RCTs, stopping rules, cost-effectiveness analysis, statistical analysis of cost-effectiveness data, survival analysis and new designs in RCTs.