NEUROSCI 705 / Neurochemistry

3 unit(s)

R.K. Mishra

A detailed analysis of the molecular mechanisms underlying the action of neurotransmitters and neuropeptides in the nervous system. Topics will include: synaptic transmission, biochemical pathways of neurotransmitters and neuropeptides, using selected examples. Basic concepts in the interactions of transmitters and peptides with their receptors, structural and pharmacological differences, receptor affinity vs. efficacy, and receptor-coupling to second messengers will be discussed. The role of neurotransmitter-peptide interactions and their relevance in selected diseases will also be addressed.